Anti-TPO and anti-Tg are major anti-thyroid antibodies that are widely used in clinical laboratories to diagnose Hashimoto’s thyroiditis disease.Siriwardhane et al showed that measurement of these antibodies was beneficial for early prediction of the development of thyroid autoimmunity and recommend adding them to the list of thyroid function tests, including FT3, FT4, and TSH.20 The gene discussed is TPO; the disease is autoimmune thyroid disease.