For confirmation of CD, auto-antibodies against tissue transglutaminase (anti-tTG - IgA), total immunoglobulin A (IgA), anti-endomysium antibody (IgA), deamidated gliadin peptide (DGP) IgA or IgG, antigliadin antibodies IgA or IgG are used.5 Along with the serological confirmation, gastrointestinal endoscopy shows scalloping of duodenal mucosa and intestinal histopathological changes like flattening of the mucosa, villous atrophy, crypt hyperplasia, infiltrative inflammatory lesions with intraepithelial lymphocytes (marsh stage 3 or 4) confirm the diagnosis of CD.27 This evidence concerns the gene TGM2 and Cowden disease.