FASN and metabolic dysfunction-associated steatotic liver disease: Previous studies have found that PPARγ promotes NAFLD formation by stimulating downstream Fasn expression, and specific knockdown of PPARγ in hepatocytes resulted in a decrease in the expression of both lipid synthesis and uptake-related genes and a reduction in the degree of hepatocyte lipid accumulation (Liu et al. 2019; Xiao et al. 2023).