2018.10 CT results: Presence of a lesion in the surgical site with surrounding invasion; observed dilatation of the left ureter; thickening of the bladder wall, potentially suggestive of tumor invasion; Presence of a nodule near the sigmoid colon, indicating a high probability of metastatic tumor. 2019.11 CEA:168.30;SCC:6.79ng/mL;CA125:4141.0U/mL 2020.07 Vaginal bleeding, hemorrhagic shock, and rectovaginal fistula. This evidence concerns the gene SERPINB3 and neoplasm.