A positive association between CHD and sex hormones was first described in 1973 (Levy et al., 1973), then corroborated by other studies (Nora et al., 1978; Hadjigeorgiou et al., 1982), including the United States Collaborative Perinatal Project (Heinonen et al., 1977). The gene discussed is PLXNA3; the disease is coronary artery disorder.