PIK3CA and ovarian carcinoma: Regarding ovarian cancer, CCC has few tumor protein 53 (TP53) mutations but frequent AT-rich interactive domain-containing protein 1A (ARID1A) and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) mutations, whereas HGSC has mostly TP53 mutations (9,10).