Recent studies have shown that glycerophospholipid metabolism plays a key role in the pathogenesis of AS and that disorders of glycerophospholipid metabolism directly affect the course of AS.[49] Inhibition of phosphatidylcholine synthesis significantly attenuated atherosclerosis by ≈80% in Ldlr−/− mice.[24d] The decrease of PC reduces the amounts of atherogenic lipoproteins by reducing VLDL secretion and increasing VLDL clearance from plasma. This evidence concerns the gene LDLR and atherosclerosis.