From the network pharmacological analysis, it can be obtained that Panax notoginseng intervenes in osteoporosis in a multi-systemic manner by affecting target genes including MAPK1, AKT1, RELA, JUN, FOS, TP53, HSP90AA1, and PPARA, regulating signaling pathways inclusive of IL-17, p53, NF-kappa B, PI3K-Akt, MAPK, FoxO, and Wnt signaling pathway, maintaining osteoblast-osteoclast balance and ameliorating bone metabolism, which firmly coincides with the holistic concept of Traditional Chinses Medicine. This evidence concerns the gene FOS and osteoporosis.