Concerning the hub genes from the PPI network depicting PN as an active ingredient for osteoporosis, According to reports in the literature, Mitogen-Activated Protein Kinase1 (MAPK1) is beneficial for anti-osteoporosis by promoting the proliferation and differentiation of osteoblasts, inducing the formation of vascular endothelial cells [48]. Here, MAPK1 is linked to osteoporosis.