The inflammatory response mediated by the interleukin-17 signaling pathway has an important regulatory role in the pathophysiological process of rheumatoid arthritis complicated by osteoporosis, and its mechanism is mainly that interleukin-17 inhibits the repair effect of proteoglycans and collagen on the matrix, thereby destroying extracellular matrix and cartilage synthesis [60]. Here, IL17A is linked to osteoporosis.