The top 20 pathways related to osteoporosis are demonstrated in Fig. (6b), which principally comprise the AGE-RAGE signaling pathway in diabetic complications, TNF signaling pathway, IL-17 signaling pathway, p53 signaling pathway, NF-kappa B signaling pathway, PI3K-Akt signaling pathway, MAPK signaling pathway, FoxO signaling pathway, and Wnt signaling pathway, etc. These are the underlying signaling mechanisms of Panax notoginseng for osteoporosis. Here, AKT1 is linked to osteoporosis.