The results showed that Panax notoginseng intervenes in osteoporosis in a multi-systemic manner by affecting target genes, including MAPK1, AKT1, RELA, JUN, FOS, TP53, HSP90AA1, and PPARA, maintaining osteoblast-osteoclast balance and ameliorating bone metabolism. This evidence concerns the gene MAPK1 and osteoporosis.