GOLPH3 and brain ischemia: For instance, GOLPH3, a member of the trans‐Golgi network protein family, is significantly overexpressed in glioma tissues, with its expression level correlating directly with tumor malignancy.[152] GOLPH3 also plays a role in the Golgi stress response, where stress‐induced upregulation of this gene leads to Golgi fragmentation and apoptosis, a process observed in cerebral ischemia‐reperfusion injury—an important pathological mechanism in ischemic stroke.