ADAM12 and neoplasm: Indeed, we sought to investigate the roles of ADAM12 and CYP1B1 in our work since they: (a) are among the most significantly upregulated genes in CAAs from overweight and obese compared to the lean subjects; (b) their expression has been proved to foster tumorigenesis and have a crucial role in tumor microenvironment; (c) ADAM12 and CYP1B1 play crucial roles in both, adipogenesis [42, 43] and tumorigenesis [35, 44].