ADAM12 and renal cell carcinoma: Conversely, ADAM12 and CYP1B1 suppression induced a reduction in RCC spheroid size when cultured with CM from overweight patient‐derived adipocytes (Fig. 5B) and even a stronger reduction in RCC spheroid size was generated by CM from obese patients‐derived adipocytes silenced for ADAM12 and CYP1B1 (Fig. 5C).