This analysis reveals that the overexpression of ADAM12 and CYP1B1 is not only important for the tumorigenesis of RCC cells but also for the secretory profile of peritumoral adipocytes, thus opening new avenues for a deeper investigation of the ADAM12 and CYP1B1‐dependent CAAs secretome. The gene discussed is CYP1B1; the disease is renal cell carcinoma.