For instance, in an MR study investigating the causal effect of elevated serum uric acid levels on chronic kidney disease (CKD) progression, SNPs related to genes such as SLC2A9 or ABC transporter genes could be used as IVs due to their established association with uric acid metabolism (p < 5 × 10−8) [45,46]. The gene discussed is SLC2A9; the disease is chronic kidney disease.