Patients with HFpEF are often prescribed standard HFrEF medications in the mistaken belief that the treatment is the same for any type of HF, not because they are indicated for other reasons, for example, Beta-blocker for heart rate control, ACE-inhibitor for hypertension. As this is generally an elderly population we need to rationalise/ take great care not to cause further problems such as falls due to inappropriate prescribing. This evidence concerns the gene ACE and hypertensive disorder.