The results indicated that the plasma protein ECM1 shared causative variation with asthma (PP.H4 = 0.95), and the cerebrospinal fluid proteins IL-6 sRa (PP.H4 = 0.97) and Layilin (PP.H4 = 0.98) shared causative variations with asthma Table 2, Supplementary Fig. 2 and Additional file 1: Table S7. The gene discussed is LAYN; the disease is asthma.