Conversely, an increase in ADAM19 (OR = 0.87; 95% CI 0.82–0.92; P = 6.17 × 10−7) and Layilin (OR = 0.61; 95% CI 0.51–0.73; P = 1.14 × 10−7) decreased the risk of asthma. Here, LAYN is linked to asthma.