Specifically, an increase in IL1-R1 (OR = 1.30; 95% CI 1.20–1.42, P = 1.63 × 10−9), IL-7R (OR = 1.07; 95% CI 1.04–1.11, P = 7.48 × 10−6), ECM1 (OR = 1.03; 95% CI 1.02–1.05, P = 2.92 × 10−5), CD200R1 (OR = 1.18; 95% CI 1.09–1.27, P = 1.74 × 10−5), and IL-6 sRa (OR = 1.29; 95% CI 1.15–1.45; P = 1.93 × 10−5) increased the risk of asthma. This evidence concerns the gene IL1R1 and asthma.