As previously stated, Wnt signaling promotes CXXC5 expression in human colon cancer cells and NSCs, and the up-regulated CXXC5 can prevent the nuclear translocation of β-catenin and the transcription of related target genes by interacting with Dvl, thereby forming a negative feedback loop for Wnt signaling [7, 8, 51]. This evidence concerns the gene CXXC5 and colonic neoplasm.