Furthermore, the downregulation of CXXC5 was found to increase the susceptibility of AML cell lines to chemotherapy-induced apoptosis, and there were differences in the activity of apoptosis between primary human AML cells with high expression of CXXC5 and low expression, suggesting that CXXC5 may influence tumor cell development by regulating cellular drug resistance and apoptosis [47, 93]. Here, CXXC5 is linked to neoplasm.