In human colon cancer cells, CXXC5 expression is upregulated by β-catenin, and the β-catenin/T-cell factor 4 (TCF4) complex has been discovered to coordinate with a chromatin loop integrated 5' and 3' Wnt responsive DNA enhancers (WREs) [7]. Here, CXXC5 is linked to malignant colon neoplasm.