In addition, dihydrotestosterone (DHT) has been discovered to upregulate CXXC5 expression via the DHT-PGD2-Smad1/5/9 axis in human immortal keratinocyte line (HaCaT), thereby inhibiting Wnt signaling via CXXC5-Dvl interaction and mediating androgenetic alopecia [26]. This evidence concerns the gene CXXC5 and androgenetic alopecia.