CXXC5 and breast cancer: Similarly, CXXC5 expression was also found to correlate with TP53 mutation status in a population of BC patients, with high CXXC5 expression correlating with wild-type TP-53 and low CXXC5 expression correlating with TP53 mutation status, suggesting that high expression of CXXC5 may inhibit apoptosis in BC cells through other pathways [87].