Inhibition of cell metabolism and colony formation, as well as elevated caspase3/7 activity, could be observed in uterine plasmacytoid carcinoma cell lines knocked down for CXXC5, suggesting that CXXC5 may promote tumor progression by inhibiting apoptosis of plasmacytoid endometrial carcinoma cells and promoting their proliferation and invasion to facilitate tumor development [91]. This evidence concerns the gene CXXC5 and neoplasm.