CXXC5 is highly expressed in mouse plasmacytoid dendritic cells (pDCs) and plays an important role in TLR7/9- and virus-induced IFN responses by recruiting Tet2 to maintain hypomethylation of specific CpG islands and stabilizing IRF7 expression. CXXC5-deficient mice are impaired in their early IFN responses and are susceptible to infection by herpes simplex virus and vesicular stomatitis virus [49]. This evidence concerns the gene CXXC5 and infection.