We conclude that a double-dose A allele in one FLT1 polymorphism (rs7993594), expressed maternally, appears to be associated with increased risk of HDP and a double dose of the G-t-G-G haplotype (rs7993594, rs3751395, rs7983774, rs664393) is associated with severe-spectrum PE/HELLP syndrome. This evidence concerns the gene FLT1 and HELLP syndrome.