CHCHD6 and amyotrophic lateral sclerosis: Amyotrophic lateral sclerosis (ALS)-linked CHCHD10 is implicated in regulating mitochondrial dynamics and respiratory complex activity (Lehmer et al, 2018; Petel Legare et al, 2023; Ruan et al, 2022; Sayles et al, 2022; Straub et al, 2018), while CHCHD6 (MIC25) participates in the cristae-remodeling MICOS complex (Ding et al, 2015; Ott et al, 2015).