Recent research has confirmed that alterations in the CHIP gene are implicated in the pathogenesis of various neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), polyglutamine diseases (PolyQ diseases), intracerebral haemorrhage (ICH), and ischaemic stroke, all of which culminate in the loss of neuronal function and manifest relevant clinical phenotypes (Kaushik et al, 2024; Kim et al, 2023; Liu et al, 2023; Zhang et al, 2020b; Zhang et al, 2024). This evidence concerns the gene STUB1 and amyotrophic lateral sclerosis.