Recent research has confirmed that alterations in the CHIP gene are implicated in the pathogenesis of various neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), polyglutamine diseases (PolyQ diseases), intracerebral haemorrhage (ICH), and ischaemic stroke, all of which culminate in the loss of neuronal function and manifest relevant clinical phenotypes (Kaushik et al, 2024; Kim et al, 2023; Liu et al, 2023; Zhang et al, 2020b; Zhang et al, 2024). The gene discussed is STUB1; the disease is ischemic stroke.