Consequently, we were able to present a single-cell transcriptome analysis of this patient, whose underlying COQ2 mutation may have predisposed him to a more severe and rapidly progressing course of IC-MPGN; the coexistence of these conditions may have synergistically contributed to the rapid deterioration of kidney function observed in this child. This evidence concerns the gene COQ2 and primary membranoproliferative glomerulonephritis.