TP53 and lung adenocarcinoma: We performed similar experiments in primary two-colour FUCCI (2F) IMR90 fibroblasts35, IMR90 HPV16 E6 and E7 (IMR90 E6E7) with compromised p53 and Rb36, p53 mutant 3F HT1080 6TG fibrosarcoma and T98G glioblastoma, p53-knockout (KO) HCT116 colorectal carcinoma and p53 wild-type 3F A549 lung adenocarcinoma cells.