EGFR and neoplasm: Briefly,we inoculated SKBR3 cells subcutaneously into female BALB/c nude mice.After 21 days (set as day 0), the following solutions were injectedinto the tumor of mice: (I) recombinant TRIM21 protein (3 μg)with PBS (TRIM21/PBS group), (II) TRIM21 with anti-EGFR antibody Ctx(1.5 μg) (TRIM21/Ctx group), (III) TRIM21 with Ctx and SR-Coa (TRIM21/Ctx/SR-Coa group), and (IV) TRIM21with Ctx and SR-Coa, subsequently followed by intratumoralinjection of an ethyl azidoacetate solution (TRIM21/Ctx/SR-Coa/ethyl azide acetate group).