Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein highly expressed on the surface of CRC cells and plays a role in cell adhesion, proliferation, and differentiation.55 An EpCAM-targeted CAR-T cell therapy evaluates safety and efficacy of IMC001 developed by ImmunoFoco in patients with advanced gastrointestinal cancers. This evidence concerns the gene EPCAM and colorectal carcinoma.