LGR5 and cancer: Leucine-rich repeat-containing G protein–coupled receptor 5 (LGR5) is frequently overexpressed in CRC and serves as a marker for cancer stem cells, which are believed to drive tumor initiation, progression, metastasis, and recurrence.40,41 LGR5 is associated with poor survival and response to therapy in metastatic CRC, making it an attractive target for CAR-T cell therapy.42 CNA3103 is a first-in-class cell product where autologous T cells are engineered to express a CAR that targets LGR5.