GUCY2C and colorectal carcinoma: Guanylyl cyclase C (GUCY2C or GCC) is a receptor primarily expressed in intestinal cells and is highly retained in metastatic CRC cells, making it a highly specific target for CAR-T cell therapy in CRC because of its limited expression in other tissues.38 Preclinical studies have demonstrated the efficacy of GUCY2C-targeted CAR-T cells in CRC models.