Fibroblast activation protein (FAP) is highly overexpressed in cancer-associated fibroblasts and is linked to poor prognosis by promoting an immunosuppressive microenvironment in various tumor types.64 Recent advances in FAP-targeting immunotherapies, including FAP-specific CAR-T cells, are being investigated in CRC mouse models.65,66. Here, FAP is linked to colorectal carcinoma.