CDH17 and colorectal carcinoma: Cadherin 17 (CDH17), involved in cell-cell adhesion, is overexpressed in gastrointestinal cancers, including CRC.60,61 The study by Feng et al demonstrated that CDH17-targeted CAR-T cells could effectively eliminate CRC cells in mouse models without damaging normal tissues.62 CHM-2101, an autologous CDH17 CAR-T cell therapy developed by Chimeric Therapeutics, is currently under evaluation in a phase I/II open-label study.