TNF and cancer: We identified distinct subclusters of breast cancer cells with specific expression patterns: metastatic breast cancer (cluster 0), hypoxic signature upregulated breast cancer (cluster 1), cancer stem‐cell‐like breast cancer (cluster 2), breast cancers expressing mTOR signaling pathways (clusters 3 and 5), and breast cancers expressing TNF‐α via NF‐kB and p53 pathways (cluster 4) (Figure 4F).