IGFBP3 and neoplasm: The cytokine array revealed that tumor spheroids with endothelial interaction exhibited higher levels of inflammatory proteins, such as IL‐8 and Pentraxin‐3 (PTX3), pro‐angiogenic proteins including insulin‐like growth factor binding proteins (IGFBP‐2 and IGFBP‐3), and anti‐angiogenic proteins like serine protease inhibitors (Serpin E1 and F1), tissue inhibitor of metalloproteinase‐1 (TIMP‐1), and thrombospondin‐1 (TSP‐1).