SSTR3 and gastric cancer: Somatostatin receptor 3 (SSTR3) stands out as a unique GPCR among the five SSTR subtypes, widely distributed throughout the brain and commonly utilized as a marker for neuronal cilia.[16] SSTR3 is involved in regulating a variety of human diseases, including stomach cancer and pituitary gonadotropin adenoma.[17] Additionally, SSTR3 plays a significant role in the establishment and remodeling of synaptic connectivity.[8, 18] Disruption of SSTR3 ciliary signaling induces alterations in neuronal excitability in rat neocortical neurons.