Numerous GPCRs and their downstream effector molecules localize to cilia on a variety of mammalian cell types.[12] Notably, GPCR signaling within the cilia plays an important role in ciliopathies and neuronal excitability.[13] In adult brain, the primary cilia are enriched with GPCRs sensitive to neurotransmitters, including dopamine (DA), serotonin (5‐HT), and somatostatin (SST). Here, SST is linked to ciliopathy.