SSTR3 and Cognitive impairment: Memory is established in neural networks through changes in synaptic strength.[37] Long‐term potentiation (LTP) is associated with synaptic plasticity and memory.[38] To investigate whether the cognitive deficit in SSTR3−/− mice was associated with altered hippocampal synaptic plasticity, LTP was induced at the hippocampal Schaffer collateral (SC) pathway and field excitatory postsynaptic potentials (fEPSPs) evoked at the CA1 region were recorded (Figure 3A).