TLR7 and viral infectious disease: To address these issues, an infection‐mimicking gel (IM‐Gel) is developed that is designed to emulate the spatiotemporal dynamics of immune stimulation in acute viral infections through in situ supramolecular self‐assembly of nanoparticulate‐TLR7/8a (NP‐TLR7/8a) and an antigen with tannic acid (TA).