CD8A and viral infectious disease: Furthermore, during acute infection, the virus can flow to the paracortex region in the dLN by penetrating LN conduits and infecting paracortical LN resident dendritic cells (DCs) within the T cell zone, leading to rapid and direct CD8+ T cell priming.[7] However, most conventional vaccines struggle to reach the paracortex because of limited access across the subcapsular sinus (SCS),[8] resulting in poor elicitation of CD8+ T cell immunity.[9] Therefore, there is an urgent need to develop a novel, next‐generation biomaterial‐based vaccine platform that mimics acute viral infections.