RAB27A and Cirrhosis: Under stress conditions, hepatocytes may exhibit enhanced EV secretion with altered EV compositions in various types of liver injury.[48] For example, steatotic hepatocytes secrete increased amounts of EVs,[14] and cirrhotic hepatocytes release increased amounts of EVs via the autophagic‐lysosomal/multivesicular body and Rab27A pathways.[19] In this study, we found higher levels of hepatic EV secretion and upregulated EV biogenesis‐related pathways (e.g., Rab27a) in the liver tissues of both patients with cirrhosis and cirrhotic mice.