Next, we ascertained whether STING inhibition could alleviate muscle injury in cirrhosis by intramuscular injection of a specific STING inhibitor (H‐151) (Figure 4J), as this inhibitor was demonstrated to suppress ISGs and cytokine expression in vivo.[23] In BDL mice, H‐151 treatment suppressed the expression of ISGs (CXCL10, ISG15, and STAT2), proinflammatory factors, and muscle injury biomarkers (Figure S7D, Supporting Information; Figure 4K,L) and enhanced body weight and grip strength (Figure 4M). This evidence concerns the gene ISG15 and Cirrhosis.