We detected mitochondrial gene expression in liver specimens from patients with cirrhosis and mouse cirrhotic models, and the results indicated decreased expression levels of mitochondrial function‐related genes (TFAM, PGC‐1α, ATP5a1, and NDUFS8) in the liver tissues of both patients with cirrhosis and mice (Figure 7A,B), reflecting severe hepatic mitochondrial injury during cirrhosis. This evidence concerns the gene PPARGC1A and Cirrhosis.