It has been reported that cGAS‐STING signaling can also induce the NF‐κB signaling pathway via TBK1 phosphorylation.[24] These results suggest that multiple pathways, such as the STING and NF‐κB pathways, can be triggered by hepatic EVs and that these pathways might form a complex network that cooperates jointly to regulate the development of cirrhosis‐associated skeletal muscle injury. This evidence concerns the gene CGAS and Cirrhosis.