Interestingly, recent studies have suggested that activation of TGFβ signaling was detrimental to IVDD, whereas inhibition of aberrant TGFβ signaling could delay IVDD progression.[41] Similarly, the protect effects of interfering with the TGFβ signaling pathway through activation of ACE2 were also validated in the treatment of osteoarthritis, a very similar degeneration‐related disease to IVDD.[38] Therefore, evidence from our study illuminates the critical role of appropriate activation of the TGFβ2/SMAD2/3 pathway for preserving NPC homeostasis and mitigating IVDD progression. This evidence concerns the gene SMAD2 and osteoarthritis.