SERPINE1, also known as plasminogen activator inhibitor 1 (PAI‐1), has been shown to promote cellular senescence.[31] Given that the aforementioned findings underscore the pivotal role of Serpine1 as a downstream regulator of senescence, we explored the therapeutic potential of modulating the expression SERPINE1 in NPC senescence. The gene discussed is SERPINE1; the disease is nasopharyngeal carcinoma.