AQP4 and brain edema: It also restored the integrity of TJs (increased the expression abundance of ZO‐1, Occludin, and Claudin‐5 by 4.3‐fold, 4.1‐fold, and 3.2‐fold, respectively), facilitated BBB endothelial repair (CD31 increased by 5.2‐fold), and prevented the occurrence of cerebral edema (AQP4 dropped by 66.9%) in the late stage of reperfusion.