It also restored the integrity of TJs (increased the expression abundance of ZO‐1, Occludin, and Claudin‐5 by 4.3‐fold, 4.1‐fold, and 3.2‐fold, respectively), facilitated BBB endothelial repair (CD31 increased by 5.2‐fold), and prevented the occurrence of cerebral edema (AQP4 dropped by 66.9%) in the late stage of reperfusion. The gene discussed is PECAM1; the disease is brain edema.