Following a single dose of BA‐loaded NPs (polymer: 3.2 mg·kg−1, BA: 400 μg·kg−1), the p‐PI3K/p‐Akt/Bcl‐2/Bax/Cyto‐C/caspase 3,9 mitochondrial apoptosis signaling pathway was mechanically regulated by the responsively dissociated borneol and released BAPTA‐AM through synchronized NPs disassembly, effectively rescuing apoptotic neurons (TUNEL‐positive cell proportion reduced by 51.6%) in MCAO mice's cerebral ischemic penumbra. This evidence concerns the gene CASP3 and cerebritis.