APP and Alzheimer disease: Woozy mice were treated with trazodone, DBM or TUDCA according to dose regimens and administration routes that have proved effective in a wide range of neurodegenerative disease mouse models, including prion-diseased mice, and transgenic rTg4510 tauP301L and APP/PS1 mice, modeling frontotemporal dementia and AD [13,21,24–27].