This study aims to fill this gap and additionally compare the prognosis between molecular GBM and histologic GBM, evaluate the impact of TERTp mutation and EGFR amplification on the prognosis of adult diffuse glioma, and explore the relationship between TERTp mutation and other molecular alterations, providing further insights into the use of TERTp within the context of the 2021 classification. Here, EGFR is linked to glioblastoma.