This was essentially what was done, because there was no significant difference in the average individual tumor volume between the Plp1-creERT/+; R26-fs-GNAQQ209L/+; Nf1 +/+ and Nf1flox/+ intradermal melanomas at euthanasia (Fig. 4A; Supplementary Table S1B). The gene discussed is PLP1; the disease is melanoma.