PGRMC1 and neoplasm: Our prognostic findings are supported by prior work noting that PGRMC1 is associated with tumor aggressiveness (14, 80, 81) and an analysis of a small patient subset (69 tumors) demonstrating that PGRMC1 overexpression is associated with breast cancer recurrence and decreased survival when untreated tumor expression is dichotomized into positive and negative PGRMC1 IHC staining (82).