The existence of an immune evasion mechanism that impairs type I IFN response during ILTV infection was speculated by Vagnozzi et al., who suggested a role for ILTV genes ICP0, VP16, US11, or US3 in interfering with or blocking type I IFN signaling during ILTV infection, as seen during infection with HSV-1 (18). This evidence concerns the gene RPS14 and infection.