Ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), AutotaxinUpregulates lysophosphatidic acid (LPA), which in turn promotes cell proliferation and immune cell chemotaxis, and hence implied in the pathogenicity of respiratory diseases in humans. Also involved in wound healing after tissue damage (57, 58). The gene discussed is ENPP2; the disease is respiratory system disorder.