In contrast, several genes were downregulated in the AOM/DSS-treated seaweed diet + B. plebeius group compared to the AOM/DSS-treated seaweed diet group, including chemokine (C-X-C motif) receptor 2 (Cxcr2), C-type lectin domain family 4, member e (Clec4e), chemokine (C-X-C motif) ligand 3 (Cxcl3), galectin-7 (Lgals7), and matrix metallopeptidase 8 (Mmp8). Here, CLEC4E is linked to infectious otitis media.