In summary, this study demonstrated that (1) Ang 1–7 improves insulin resistance and glucose tolerance in dietary-induced obese mice, (2) Ang 1–7 reduces MCP-1 at local (eWAT) and systemic levels, accompanied by a reduction in the number of CLS in eWAT of dietary-induced obese mice, (3) Ang 1–7 attenuates MCP-1 secretion in hypertrophic and TNF-α-exposed 3T3-L1 adipocytes, (4) Ang 1–7 reduces TNF-α at local (eWAT) and systemic levels in dietary-induced obese mice, and (5) Ang 1–7 attenuates TNF-α secretion in lipotoxic model of macrophages. The gene discussed is ANGPT1; the disease is Insulin resistance.