The higher abundance of 14-3-3 proteins (YWHAG,YWHAQ, YWHAE, and SFN) in saliva, first reported here, may be associatedwith increased infectivity and improved viral replicative fitness.We also identified seven proteins (ACTN1, H2AC2, GSN, NDKA, CD109,GGH, and PCYOX) that yielded comprehension into Omicron infectionand performed outstandingly in screening patients with COVID-19 ina hospital setting. Here, YWHAE is linked to COVID-19.