When evaluated DEG in choroid plexus epithelial cells, genes encoding solute transporters reported to be upregulated in the hydrocephalus model48, forming complex together with SPAK (Stk39), including NKCC1 (Slc12a2), CLIC6 (Clic6) and KCNJ13 (Kcnj13) were more abundant in ApoE-KO; BAC/APOL1-G1 mice (Figure 2D, 2E). Here, SLC12A2 is linked to Hydrocephalus.