For instance, a recent study reported that an individual with a rare gain of function mutation in the RELN gene (RELN COLBOS), that encodes the protein Reelin, was resilient to autosomal dominant AD, showing low tau burden in the EC despite high amyloid load, and a 25 year-delay in cognitive impairment from the expected onset9. This evidence concerns the gene RELN and Cognitive impairment.