Moreover, TRM-AMs in the non-solid and solid component showed decreased expression of TRM-AM markers (FABP4, PDLIM1 and IGFBP2) and increased expression of MoMac markers (BASP1, CEBPD, TMEM176B, TREM2, APOE, A2M, SPP1, MARCKS), suggesting that the TRM-AMs may have been reprogramed into tumor-associated macrophage in the non-solid and solid nodules (Supplementary Fig. 4.2g). This evidence concerns the gene SPP1 and neoplasm.