COL1A1 and neoplasm: In addition to protumorigenic genes observed in the tumor transiting population above, there was upregulation of (i) COL1A1 (Collagen type I alpha 1) which promotes epithelial-to-mesenchymal transition (EMT), and confers poor prognosis26,27; (ii) ABCC3 (ATP Binding Cassette Subfamily C Member 3) known to confer multidrug resistance in lung cancer28; (iii) CEACAM624; and (iv) LAPTM4B (Lysosomal Protein Transmembrane 4 Beta), an oncogene known to stimulate tumor growth29 (Fig. 2f).