Xu et al. (2015) found that perinatal exposure to Di-(2-ethylhexyl)-Phthalate (DEHP) enhances anxiety and depression-like behaviors in offspring mice, potentially interfering with gonadal hormone activity through alterations in the hippocampal expression of both androgen receptor (AR) and estrogen receptor beta (ERb) (Xu et al., 2015). The gene discussed is ESR2; the disease is major depressive disorder.