Especially, chlorogenic acid and polymatin B were seen interacting with maximum catalytic site amino acid of PPAR‐γ (Nolte et al. 1998), including HIS 449, SER 289, ARG 288 and LEU 330, and ILE 341 (Figure 6), respectively, via strong hydrogen bond resulting the maximum binding energy of −7.2 and − 8.2 kcal/m, representing a strong ligand‐protein complex and provide a precious drug candidates for diabetes. This evidence concerns the gene PPARG and diabetes mellitus.