The top 10 targets of CT against GBM included tumor protein 53 (TP53), TNF, caspase‐3, estrogen receptor 1(ESR1), Matrix metalloproteinase‐9 (MMP‐9), C‐C motif chemokine ligand 2 (CCL2), prostaglandin‐endoperoxide synthase 2 (PTGS2), reticuloendotheliosis viral oncogene homolog A (RELA), Forkhead box protein O1 (FOXO1), and JAK2 (Figure 3). This evidence concerns the gene ESR1 and glioblastoma.