In this study, AlCl3/D‐gal induced a significant decrease in Nrf2 and HO‐1 expression in the CA1 and CA3 regions of the brain tissue of AD mice, and the administration of DAP and DAP4 upregulated the expression of Nrf2 and HO‐1 in the CA1 and CA3 regions. Here, HMOX1 is linked to Alzheimer disease.