IGHE and allergic disease: While a large body of evidence suggests that Immunoglobulin E (IgE) and mast cells are key drivers in allergic disease, mast cells playing an important role in the induction of allergic inflammation by releasing various mediators, including lipid mediators, chemokines and cytokines, as important effector cells (Galli and Tsai 2012; Gilfillan and Beaven 2011).