2022). From our study, persistent hyperglycemia led to the upregulation of NFKβ in diabetic control animals while BMEE treatment was able to down regulate the expression of NFKβ significantly indicating improved glucose tolerance and reduced insulin resistance in the treated diabetic animals. In the early phases of diabetes type 2, NFKβ signaling and the liver's synthesis of pro‐inflammatory mediators lead to insulin resistance and pathogenesis of diabetic vascular complications (Meyerovich, Ortis, and Cardozo 2018). This evidence concerns the gene NFKB1 and type 2 diabetes mellitus.