Biomarkers of acromegaly at the time of entry into the registry showed elevated levels of IGF-1 and GH with no differences by sex (IGF-1 800 ng/mL; RIC, 517 to 1076 ng/mL, and GH 14 ng/mL; IQR, 5.85 to 25 ng/mL, respectively). The gene discussed is IGF1; the disease is acromegaly.