Genetic variants of PA include familial hyperaldosteronism (FH) types I-IV, FH type I is caused by CYP11B1/CYP11B2 (cytochrome P450 family 11 subfamily B members 1 and 2) chimeric gene mutation, FH type II due to CLCN2 (chloride voltage-gated channel 2) pathogenic variants, FH type III due to KCNJ5 (potassium inwardly rectifying channel subfamily J member 5 gene) pathogenic variants and FH type IV due to CACNA1H (calcium voltage-gated channel subunit alpha1 H) pathogenic variants. This evidence concerns the gene KCNJ5 and familial hyperaldosteronism.