In one LS-SCLC cohort, the most frequently altered genes were TP53 (91%), RB1 (57%), KMT2D (18%), PTPRT (7%), NOTCH1 (5%), and STK11 (5%), which is similar to the alteration profiles seen in ES-SCLC[127]. This evidence concerns the gene NOTCH1 and small cell lung carcinoma.