Studies have shown that EV-delivered circular RNA F-box and WD repeat domain-containing 7 (circ-FBXW7) can bind to miR-128-5p and restore oxaliplatin sensitivity in resistant CRC cells by inhibiting drug efflux, thus providing a novel treatment strategy for patients with CRC with oxaliplatin resistance[206]. This evidence concerns the gene FBXW7 and colorectal carcinoma.