Initially, tumor cells overexpress immune checkpoint molecules such as PD-L1 (programmed death-ligand 1), TIM-3 (T-cell immunoglobulin and mucin-domain containing-3), LAG-3 (lymphocyte-activation gene 3), and VISTA (V-domain Ig suppressor of T cell activation), which inhibit T cell activation by binding to their respective receptors[175]. This evidence concerns the gene CD274 and neoplasm.