PTPN11 and cancer: Although no excess cancer risk in adults or significantly different time-dependent penetrance of cancer was observed in NS-heterozygotes, one XY individual who was heterozygous for a P/LP variant in PTPN11 had a history of a malignant neoplasm of the testis (at age 27.8) and breast cancer (at age 62) in the UKBB merits comment.