MDM4 and melanoma: Fine-mapping of this locus identified a second independent-but-marginal melanoma GWAS signal over the MDM4 gene itself (rs12119098, P = 1.30 × 10−7; Figure S15), a signal that colocalizes with a significant melanocyte MDM4 eQTL (P = 5.83 × 10−6; Figure S15), considerably strengthening the evidence for a role for MDM4 in melanoma susceptibility and potentially resolving a role for MDM4 in promoting or alternatively protecting against melanoma.