We note that a previously-published small pooled CRISPR knockout screen in melanocytes47 found that MDM4 knockout significantly reduced melanocyte viability and/or growth (FDR = 0.000102), and both RNAi and CRISPR screen data from the Cancer Dependency Map project125 show MDM4 knockout to be strongly selective in the same direction. This evidence concerns the gene MDM4 and cancer.