MDM4 and cancer: This locus appears to be potentially pleiotropic in terms of cancer risk; rs12133735 near MDM4 has been reported as a suggestive association for aerodigestive squamous cell cancers (rs12133735 LD to rs12119098 r2 = 0.82), where the rs12133735-G risk allele is on a shared haplotype with the melanoma rs12119098-G protective allele126.