Finally, for MDM4 (locus 4, signal 4), all three gRNAs for one of the four SNPs tested (rs6700182; interacts with MDM4; within melanocyte and melanoma ChromHMM regulatory region; MPRA-significant in melanoma) showed significantly reduced MDM4 levels (0.82–0.85-fold expression relative to NTC1; Table S22); only one of these variants reduced expression of another candidate in this region, RBBP5, with no effect on a third candidate, TMEM81. This evidence concerns the gene TMEM81 and melanoma.