Of these, three have well characterized pathogenic protein coding changes (signal 9, MITF100,101; signal 14, SLC45A292,95–97; and signal 42, TYR2,10,92,98,99, while three others harbor known melanoma driver or pigmentation genes (signal 11, TERT; signal 12, TERT; signal 50, OCA2;)5,108–110. Here, OCA2 is linked to melanoma.